David Rottenberg, MSc (Cantab), MD

Rottenberg

Academic Title

Professor of Neurology

Clinical Title

University of Minnesota Physician

Education

Medical School
Harvard Medical School

Residency (Neurology)
The New York Hospital

Specialization (Neuro-oncology)
Memorial Sloan-Kettering Cancer Center

BA, English Literature
University of Michgan

MSc, Biochemistry
Cambridge University (UK)

Other Education
Research Associate, NINDS, NIH

Contact Info

Email
rotte001@umn.edu

Phone
Office: 612-467-4784

Fax
Office (VAMC): 612-727-5693

Administrative Contact
Katie Sanders
612-625-5993

Office Address
Department of Neurology
University of Minnesota
420 Delaware St. SE
Minneapolis, MN 55455

Mailing Address
Department of Neurology
University of Minnesota
MMC 295, 420 Delaware St. SE
Minneapolis, MN 55455

More Information

Bio Statement

On March 25th, 1963 I received a letter from the British Ambassador to the United States, Sir David Ormsby Gore, stating that I had been awarded a Marshall Scholarship tenable at what is now Fitzwilliam College. Though I was excited by the prospect of spending two years in the UK, I was also undecided having just received a letter from the Harvard Medical School congratulating me on my admission to the Class of '63. In the event, I made my choice and never looked back.

At Cambridge I worked in a biochemistry laboratory with a Sicilian princess who taught me Italian, and I studied Russian with an émigré family in London. On my return to the US I was admitted to the Class of 1965 at Harvard Medical School. At Harvard I pursued my interest in languages, spending one summer in at the Università degli Studi in Milano and another in the slums of Bogotá studying the causes of protein malnutrition, and in 1968 I took a year off to participate in the US-USSR Cultural Exchange. As luck would have it, I arrived in Moscow one day before the Russians invaded Czechoslovakia. Caught up in the Cold War and unable to extend my visa, my wife and I decided to return to England in October, and I spent the remainder of the academic year as a medical student at Guy's Hospital in London.

After graduating from medical school I spent two years as a Research Associate at the National Institutes of Health (NIH), trained under Fred Plum and Jerry Posner as a neurologist with special expertise in neuro-oncology, headed an NIH-and NSF-funded neuroimaging research enterprise for 15 years, and expanded my interest in spoken languages to include a number of computer languages. In addition to my practice of neurology, now mostly limited to movement disorders and deep brain stimulation, I currently sit on the editorial boards of medical and scientific journals and consult for government and industry.

Research Interests

For the past 30 years my research has focused on quantitative neuroimaging — most notably on CT, PET, MRI and fMRI — computational neuroanatomy, and scientific visualization. In particular I have been interested in the analysis of PET and fMRI time-series data, the generation of surface-based maps of functional activation and cortical thickness, and the creation of computerized methods for visualizing multi-dimensional data at single points in stereotactic anatomical space. I have been involved in the development and evaluation of bias-field-correction and tissue-segmentation algorithms and MRI/fMRI image-processing pipelines, and I have used quantitative neuroimaging techniques to study patients with disorders of consciousness, cancer, AIDS, Parkinson's disease, and genetically-defined ataxic disorders.

MENTORING

My approach to mentoring is based on guidance rather than direct assistance — guidance with regard to study design, data acquisition, data analysis, and manuscript preparation.

Research Grants

Teacher Investigator Award, K07NS00286: l977–1982

Research Center in Cerebrovascular Disease, P01NS03346: 1979–1984 (PI, Project 1C: The Quantitative Assessment of Cerebral Edema using Computed Tomography)

Research Center in Cerebrovascular Disease, P01NS03346: 1984–1989 (PI, Project 4: The Functional Anatomy of Human Amnesia)

Positron Emission Tomography of the CNS, P01NS15665: 1979–1984 (Co-PI); 1984–1989 (Program Director)

Program in Cognitive Neuroscience, P01NS17778: 1982–1985 (PI, Project 7: Behavioral Studies During PET Imaging with CO15O)

Regional Brain Metabolism in Viral Encephalitis, R01NS19048: 1986–1989 (Co-Investigator)

Intravenous vs. Intra-arterial Cisplatin Chemotherapy of Malignant Brain Tumors, Bristol-Myers: 1984–1987 (PI)

Clinical and Animal Studies on the Biological Basis of Memory, McKnight Foundation: 1980–85 (Co-Investigator)

Eikonix EC 785-Vax 11/730-Gould DeAnza IP8400 Image Processing System, S10RR02361: 1984–87 (PI)

A Quantitative Study of the AIDS Dementia Complex Using Positron Emission Tomography and [18F]fluorodeoxyglucose, P01NS2570: 1988–1998 (PI, Project 2)

Metabolic Anatomy of Olfaction in the Rat, Veterans Administration (RAG): 1990–1991 (PI)

Human Brain Atrophy and Dysfunction in Chronic Cocainism, R01DA07428: 1991–1995 (PI, VAMC Subcontract)

Visualization of Functional Connectivity in the Brain, R01DA09246: 1994–1996 (PI)

Quantitative Assessment of Functional Connectivity in the Hereditary Ataxias, P01NS33718: 1995–1999 (PI, Project 4)

Spatial and Temporal Patterns in Functional Neuroimaging, P20 MH57180: 1996–2007 (Program Director)

Correlation of Cholinergic Reserve and Cognitive Function with Positron Emission Tomography, Alzheimer's Association: LOI-96-001: 1996–1998 (Co-Investigator)

Computational Conformal Mapping and Scientific Visualization: NSF-00-114: 2001–2004 (co-PI)

Spatial and Temporal Patterns in Functional Neuroimaging, P20 MH57180-07S1A1: 2002–2006 (PI)

Clinical Trials

1. CCOM998 US01 (5/2000–12/2001). A multi-center, double-blind, placebo-controlled study of the tolerability and effect of entacapone in Parkinson's subjects with end-of-dose wearing-off symptoms occurring no earlier than 4 hours after their most recent carbidopa/levodopa dose.

2. RO1 NS34796 (4/2001–6/2002). Earlier vs. later l-dopa in Parkinson's disease.

3. TVP 1012/133 (10/2000–1/2003). A multi-center, US and Canada, double-blind, randomized, placebo-controlled, parallel group study of the efficacy, tolerability and safety of rasagiline mesylate in Parkinson's disease patients with motor fluctuations.

4. TVP 1012/135 (5/2002–9/2005 ). An active extension of the TVP 1012/133 study: A bi-national, multi-center, double-blind, randomized study to evaluate the safety and tolerability of rasagiline mesylate in advanced Parkinson's disease patients with motor fluctuations treated with chronic levodopa/carbidopa therapy.

5. TVP 1012/135 (9/2005– ). An open-label phase of TVP 1012/135.

6. SP650 (7/2002–5/2008). A multi-center, multi-national, Phase III, randomized, double-blind, parallel group, placebo-controlled trial of the efficacy and safety of rotigotine CDS patch (2 target doses) in subjects with advanced stage, idiopathic Parkinson's disease who are not well controlled on levodopa (Part I) and open-label extension to assess the safety of long-term treatment of rotigotine CDS (Part II).

7. EP002 (1/2003–7/2003). A survey to assess the incidence and characteristics of melanoma in Parkinson's disease patients.

8. SAD-PD (R01 NS046487-01A1, 7/1/04–4/30/08). A study of antidepressants in Parkinson's disease.

Selected Peer-Reviewed Publications (of 136)

Rottenberg DA, Chernik NL, Deck MDF, Ellis F, Posner JB. Cerebral necrosis following radiotherapy of extracranial neoplasms. Ann Neurol. 1977;1:339-357.

Rottenberg DA, Horten B, Kim J-H, Posner JB. Progressive white matter destruction following radiation therapy of an extracranial neoplasm. Ann Neurol. 1980;8:76-78.

Rottenberg DA, Ginos JZ, Kearfott KJ, Junck L, Dhawan V, Jarden DO. In vivo measurement of brain tumor pH using 11C-DMO and positron emission tomography. Ann Neurol. 1985;17:70-79.

Junck L, Dhawan V, Thaler HT, Rottenberg DA. Effects of xenon and krypton on regional cerebral blood flow in the rat. J Cereb Blood Flow Metab. 1985;5:126-132.

Jarden JO, Dhawan V, Poltorak A, Posner JB, Rottenberg DA. Positron emission tomographic measurement of blood-to-brain and blood-to-tumor transport of 82Rb: The effect of dexamethasone and whole-brain radiation therapy. Ann Neurol. 1985;18:636-646.

Arnold JB, Kraig RP, Rottenberg DA. In vivo measurement of regional brain and tumor pH using [14C]dimethyloxazolidinedione and quantitative autoradiography II: Characterization of the extracellular fluid compartment using pH-sensitive microelectrodes and [14C]sucrose. J Cereb Blood Flow Metab. 1986;6:435-440.

Phillips PC, Dhawan V, Strother SC, Sidtis JJ, Evans AC, Allen JC, Rottenberg DA. Reduced cerebral glucose metabolism and increased brain capillary permeability following high-dose methotrexate chemotherapy: A positron emission tomographic study. Ann Neurol. 1987;21:59-63.

Rottenberg DA, Moeller JR, Strother SC, Sidtis JJ, Navia BA, Dhawan V, Ginos JZ, Price PW. The metabolic pathology of the AIDS dementia complex. Ann Neurol. 1987;22:700-706.

Rottenberg DA, Moeller JR, Strother SC, Sidtis JJ, Navia BA, Dhawan V, Ginos JZ, Price PW. The metabolic pathology of the AIDS dementia complex. Ann Neurol. 1987;22:700-706.

Anderson NE, Posner JB, Sidtis JJ, Moeller JR, Strother SC, Dhawan V, Rottenberg DA. The metabolic anatomy of paraneoplastic cerebellar degeneration. Ann Neurol. 1988;23:533-540.

. Eidelberg D, Moeller JR, Dhawan V, Sidtis JJ, Ginos JZ, Strother SC, Cedarbaum J, Greene P, Fahn S, Rottenberg DA. The metabolic anatomy of Parkinson's disease: complementary 18F-fluorodeoxyglucose and 18F-fluorodopa positron emission tomographic studies. Movement Disorders. 1990; 5:203-213.

Strother SC, Kanno I, Rottenberg DA. Principal component analysis, variance partitioning and "functional connectivity". J Cereb Blood Flow Metab. 1995;15:353-360.

Strother SC, Anderson J, Hansen LK, Kjems U, Kustra R, Sidtis J, Frutiger S, Muley S, LaConte S, Rottenberg DA. The quantitative evaluation of functional neuroimaging experiments: The NPAIRS data analysis framework. NeuroImage. 2002;15:747-771.

Liang L, Rehm K, Woods RP, Rottenberg DA. Automatic segmentation of left and right cerebral hemispheres from MRI brain volumes using the Graph Cuts algorithm. NeuroImage. 2007;34(3):1160-1170.

Rottenberg DA. Thin Skin: the cortical signature of prodromal AD? Neurology. 2009;72:1038-1039 (editorial).

Books, Book Chapters and Review Articles

BOOKS

Rottenberg DA, Hochberg F, eds. Neurological Classics in Modern Translation. New York: Hafner Press, 1977.

Rottenberg DA, ed. Neurological Complications of Cancer Treatment. Boston: Butterworths, 1990.

BOOK CHAPTERS AND REVIEW ARTICLES

1. Rottenberg DA, Posner JB. Intracranial Pressure Control. In Cottrell JE, Turndorf H, eds. Anesthesia and Neurosurgery. St. Louis: The C.V. Mosby Company, 1980: 89-118.

2. Rottenberg DA. The pathophysiology of intracranial hypertension/hypotension. In Intracranial Pressure IV. New York: Springer-Verlag, 1980: 517-519.

3. Rottenberg DA, Cooper AJL. Emerging Techniques: Positron emission tomography of the central nervous system. Trends Biochem Sci. 1981; 6:120-122.

4. Rottenberg DA, Ginos JZ, Kearfott KJ, Junck LR, Conti J, Dhawan V. Feasibility of measuring regional brain tissue pH using 11C-dimethyloxazolidinedione and positron emission tomography: Preliminary observations in animals and man. In Workshop on Time-of-Flight Tomography. Silver Spring: IEEE Computer Society, 1982:15-18.

5. Rottenberg DA, Ginos JZ, Kearfott KJ, Junck LR, Bigner DD. In vivo measurement of regional brain tissue pH using positron emission tomography. Ann Neurol. 1984; 15[Suppl]: S98-S102.

6. Rottenberg DA, Ginos JZ, Kearfott KJ. Assessment of regional cerebral acid-base status in man using 11C-dimethyloxazolidinedione and positron emission tomography. In Greitz T, Widen L et al., eds. The Metabolism of the Human Brain Studied with Positron Emission Tomography. New York: Raven Press, 1985:279-284.

7. Rottenberg DA. Intracranial Hypotension, Intracranial Hypertension, Pseudotumor Cerebri, Hydrocephalus. In Wyndgaarden JB, Smith LH Jr, Plum F, eds. Cecil Textbook of Medicine, 17th Edition. Philadelphia: W.B. Saunders Co., 1985.

8. Rottenberg DA. Intracranial Hypotension, Intracranial Hypertension, Pseudotumor Cerebri, Hydrocephalus. In Wyndgaarden JB, Smith LH Jr, Plum F, eds. Cecil Textbook of Medicine, 18th Edition. Philadelphia: W.B. Saunders Co., 1988.

9. Rottenberg DA. Acute and Chronic Effects of Radiation Therapy on the Nervous System. In Rottenberg DA, ed. Neurological Complications of Cancer Treatment. Boston: Butterworths, 1990.

10. Glantz MJ and Rottenberg DA. Harmful Effects of Radiation on the Nervous System. In Asbury AK, McKhann GM, McDonald I, eds. Diseases of the Nervous System. Philadelphia: W.B. Saunders, 1992.

11. Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Wells TH, Barrett JN, Grafton ST, Mazziotta JC, Eidelberg D, Rottenberg DA. Therapeutic effects of human fetal dopamine cell transplants in a patient with Parkinson's disease. In Dunnett SB and Richards SJ, eds. Progress in Brain Research (Proceedings of the IIIrd International Symposium on Neural Transplantation, Cambridge, UK, August 6-11, 1989). Elsevier Science Publishers B.V., 1990:715-721.

12. Vick NA, Rottenberg DA. Disorders of Intracranial Pressure. In Wyndgaarden JB, Smith LH Jr, Bennett JC, eds. Cecil Textbook of Medicine, 19th Edition, W.B. Saunders Co., Philadelphia. 1992.

13. Bencherif B, Price RW, Rottenberg DA. Neuroimaging of the AIDS Dementia Complex. In Fazekas F, Schmidt R, Alavi A, eds. Neuroimaging of Normal Aging and Uncommon Causes of Dementia, Dordrecht: ICG Publications, 1998.

14. Strother SC, Anderson JR, Schaper KA, Sidtis JJ, Rottenberg DA. Linear models of orthogonal subspaces and networks from functional activation PET studies of the human brain, Bixais Y, Barillot C, Di Paola R, eds. Information Processing in Medical Imaging. 14th International Conference) Kluwer Academic, Amsterdam, pp. 299-310, 1995.

15. Peterson K, Rottenberg DA. Radiation Damage to the Brain. In Vinken PJ and Bruyn GW, eds. Handbook of Clinical Neurology, Amsterdam: Elsevier Science, 1997.

16. Hurdal MK, Bowers PL, Stephenson K, Sumners DWL, Rehm K, Schaper K, Rottenberg DA. Quasi-conformally Flat Mapping the Human Cerebellum. In: MICCAI’99—Image Computing and Computer-Assisted Intervention, Taylor C and Colchester A, eds. Lecture Notes in Computer Science 1679, Springer, Berlin. pp. 279-286, 1999.

17. Sidtis JJ, Anderson JR, Rottenberg DA. Establishing Behavioral Correlates of Functional Imaging Signals. In Gjedde A, Hansen S, Knudsen GM and Paulson OB, eds. Physiological Imaging of the Brain with PET, Academic Press, New York. pp. 305-308, 2000.