Ashe Laboratory: Karen Ashe, PI


Dr. Ashe's laboratory's research works to better understand the mechanism and diagnosis of Alzheimer's disease. Transgenic mouse models of Alzheimer's disease are created and used to learn how specific proteins (tau and Aβ*) disrupt brain function using biochemical and behavioral techniques. Research using mouse models is complemented by biochemical analysis and study of human samples in collaboration with clinical scientists.

Dr. Ashe's discoveries include the memory-impairing Aβ*56 protein assembly and proof that neurofibrillary tangles do not cause irreversible memory loss.



Principal Investigator

  • Karen H. Ashe, MD, PhD
    Professor, Department of Neurology
    Founding Director, N. Bud Grossman Center for Memory Research and Care
    Edmund Wallace and Anne Marie Tulloch Chairs in Neurology and Neuroscience

Laboratory Listing


Volunteers and Positions

Undergraduates, Graduates and Postdocs

  • Undergraduate and graduate students and post-doctoral researchers interested in research employment opportunities with Dr. Karen Ashe should email their cover letter, CV, and list of references to Undergraduates should also send their unofficial transcript and must be able to make an 18-month commitment to be considered for hire.
  • The Ashe Laboratory is not currently hiring for any professional, academic, or technical positions. Postings may be found online through the University's Employment System when we are hiring.

Maps and Directions


Main Research Office: 612-625-0963  e-mail

Physical Address for Mailing and Shipping
Ashe Laboratory, G-CRMC, Room 5-280
Wallin Medical Biosciences Building (WMBB)
2101 6th Street SE, Minneapolis, MN 55455-3008

Campus Mail: Ashe Laboratory, G-CMRC, WMBB 5-280, CDC 2641F

Main Research Office, Grossman Center: 612-625-0963  e-mail

Ashe Laboratory: 612-625-5654

For Details and Directions click here.